Title: Glycemic Control and Cardiovascular Risk <br/>Author: Semhar Tewelde<br/><a href='http://umem.org/profiles/faculty/352/'>[Click to email author]</a><hr/><p>
Tight glycemic control (HbA1C<7%) has previously been recommended in CAD based on data from the United Kingdom Prospective Diabetes Study (UKPDS)</p>
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A recent study (JACC) evaluated the relationship between glycemic control, cardiovascular disease (CVD) risk, and all-cause mortality </p>
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Patients with a mean HbA1C 7-7.4% were compared to those with mean HbA1C <6%; tight glycemic control had a 68% increased risk of CVD hospitalization</p>
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Lenient HbA1C>8.5% also had significantly higher risk</p>
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CVD risk and all-cause mortality is greater with both aggressive and lax glycemic control and the optimal reference range may lie between 7-7.4%</p>
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Nichols G, Joshua-Gotlib S, Parasuraman. Glycemic Control and Risk of Cardiovascular Disease Hospitalization and All-Cause Mortality. JACC. 62: 2; 121-127.</p>
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