Title: Follow Up on Phenergan IV - Why Not IM<br/>Author: Fermin Barrueto<br/><a href='http://umem.org/profiles/faculty/74/'>[Click to email author]</a><hr/><p>
Yesterday's pearl generated several questions that I thought were worth answering briefly:</p>
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1) Why give it IM? Absorption rate is faster than SQ infiltration though theoretically could still cause necrosis</p>
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2) Is it only infilitration? Gangrene has occurred with inadvertent intra-arterial injection, SQ infiltration and even regular IV administration</p>
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3) Mechanism? Appears to be the drug and not diluent, diluting down the concentration as well as decreasing dose appears to help if you are going to give it IV</p>
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Here is a website if you wish to read more details:</p>
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https://www.ismp.org/newsletters/acutecare/articles/20060810.asp</p>
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