Title: Perinatally Infected HIV & Cardiovascular Disease <br/>Author: Semhar Tewelde<br/><a href='http://umem.org/profiles/faculty/352/'>[Click to email author]</a><hr/><p>
<strong><u>Perinatally Infected HIV & Cardiovascular Disease</u></strong></p>
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*Perinatally HIV-infected adolescents are susceptible to aggregate atherosclerotic cardiovascular disease risk, but few studies have quantified risk or developed a scoring system</p>
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*A recent study of perinatally HIV-infected adolescents calculated coronary artery and abdominal aorta PDAY (Pathobiological Determinants of Atherosclerosis in Youth) scores using modifiable risk factors: HTN, HLD, smoking, obesity and hyperglycemia</p>
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*Significant predictors of a high coronary arteries and abdominal aorta scores include: male sex, Hx AIDS-defining condition, long duration of ritonavir-boosted protease inhibitor, and no prior use of tenofovir</p>
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*PDAY scores may be useful in identifying high-risk youth who may benefit from early lifestyle or clinical interventions given their trend of increased aggregate atherosclerotic cardiovascular disease risk factor burden</p>
<fieldset><legend>References</legend>
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Patel K, Et al. Aggregate Risk of Cardiovascular Disease Among Adolescents in Perinatally Infected with the Human Immunodeficiency Virus. Circulation Vol 129(11) 18 March 2014, p1204-1212.</p>
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