Title: Predictors of Failure of Outpatient Antibiotics for ED Cellulitis Patients<br/>Author: Bryan Hayes<br/><a href='http://umem.org/profiles/faculty/369/'>[Click to email author]</a><hr/><p>
In a prospective cohort of 598 ED patients, 5 risk factors were independently associated <span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.999801635742188px;">with uncomplicated cellulitis patients who fail initial antibiotic therapy as outpatients and require a change of antibiotics or admission to hospital</span>: </p>
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<span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.999801635742188px;">Fever (temperature > 38°C) at triage (OR = 4.3, 95% CI = 1.6 to 11.7)</span></li>
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<span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.999801635742188px;">Chronic leg ulcers (OR = 2.5, 95% CI = 1.1 to 5.2)</span></li>
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<span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.999801635742188px;">Chronic edema or lymphedema (OR = 2.5, 95% CI = 1.5 to 4.2)</span></li>
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<span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.999801635742188px;">Prior cellulitis in the same area (OR = 2.1, 95% CI = 1.3 to 3.5)</span></li>
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<span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.999801635742188px;">Cellulitis at a wound site (OR = 1.9, 95% CI = 1.2 to 3.0)</span></li>
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<span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17.999801635742188px;">Patients presenting with uncomplicated cellulitis and any of these risk factors may need to be considered for observation +/- IV antibiotics.</span></p>
<fieldset><legend>References</legend>
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Predictors of Failure of Empiric Outpatient Antibiotic Therapy in Emergency Department Patients with Uncomplicated Cellulitis. <em>Acad Emerg Med</em> 2014; 21(5):526-31. [<a href="http://www.ncbi.nlm.nih.gov/pubmed/24842503">PMID 24842503</a>]</p>
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