Title: Risk of infection from blood transfusions<br/>Author: Feras Khan<br/><a href='http://umem.org/profiles/faculty/1145/'>[Click to email author]</a><hr/><p>
<strong>Risk of infection from Blood transfusions</strong></p>
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We are already moving to decreasing transfusions in general for most of our hospital patients</li>
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But now there is evidence that more transfusions can lead to an increase in nosocomial infections</li>
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<strong>JAMA Meta-Analysis</strong></p>
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18 randomized trials with 7,593 patients</li>
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All tested higher vs lower transfusion thresholds in a variety of inpatient settings</li>
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Hospital-acquired infections were the outcome</li>
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<strong>What they found</strong></p>
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Absolute risk for nosocomial infection was 17% among patients with a higher hemoglobin target compared to 12% with a lower target</li>
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NNT to avoid an infection was 38 using a restrictive transfusion strategy</li>
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<strong>Bottom Line</strong></p>
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Potential cost savings to the healthcare industry with less transfusions</li>
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For <em>most</em> patients, a hemoglobin > 7 g/dL is just fine</li>
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<fieldset><legend>References</legend>
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Rohde J, et al. Health Care Associated Infection after Red Blood Cell Transfusion. A systematic Review adn Meta-Analysis. JAMA 2014; 311(13): 1317-1326. </p>
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