Title: Clindamycin's Role in Skin and Soft Tissue Infections<br/>Author: Bryan Hayes<br/><a href='http://umem.org/profiles/faculty/369/'>[Click to email author]</a><hr/><p>
Clindamycin used to be a first-line agent for many SSTIs, particularly where MRSA was suspected. With growing resistance to staph species, the 2014 IDSA Guidelines recommend clindamycin as an option only in the following situations:</p>
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Nonpurulent SSTI (primarily <u>strep</u> species)
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Mild - oral clindamycin</li>
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Moderate - IV clindamcyin</li>
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Severe, necrotizing infections - adjunctive clindamycin only with suspected or culture-confirmed strep pyogenes</li>
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Purulent SSTI (primarily <u>staph</u> species)
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Clindamycin only recommended in moderate or severe cases if cultures yield MSSA</li>
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* Clindamycin may be used if clindamycin resistance is <10-15% at the institution.</p>
<fieldset><legend>References</legend>
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Stevens DL, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. <em>Clin Infect Dis</em> 2014;59(2):e10-52. [<a href="http://www.ncbi.nlm.nih.gov/pubmed/24947530">PMID 24947530</a>]</p>
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<strong>Follow me on Twitter (<a href="https://twitter.com/PharmERToxGuy">@PharmERToxGuy</a>) or Google Plus (+bryanhayes13)</strong></p>
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