Title: Risk Factors for Invasive Candidiasis<br/>Author: Feras Khan<br/><a href='http://umem.org/profiles/faculty/1145/'>[Click to email author]</a><hr/><ul> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Invasive candidal infections can carry a high mortality (up to 40%) and can hard to diagnose</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">In the ICU it is important to know which patients are at risk for developing invasive candidal infections</span></span></li> </ul> <p> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;"><strong>Risk factors for invasive candidal infections</strong></span></span></p> <ul> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Critical illness (long ICU stays)</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Abdominal surgery (anastomotic leaks, repeat laporatomies)</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Necrotizing pancreatitis</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Hematologic malignencies</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Solid organ transplant</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Solid organ tumors</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Neonates (low birth wt, preterm)</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Use of broad spectrum antibiotics</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Central lines/PICC lines</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">TPN</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Hemodialysis</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Steroid use</span></span></li> <li> <span style="font-size:12px;"><span style="font-family:times new roman,times,serif;">Candidal colinization (urine, sputum) </span></span></li> </ul> <fieldset><legend>References</legend>
<h1 style="margin: 0px; padding: 8px 0px; border: 0px; outline: 0px; font-weight: normal; font-size: 1.45em; vertical-align: baseline; line-height: 1.05em; background-image: none; font-family: 'times new roman';"> Invasive Candidiasis</h1> <p class="authors" style="margin: 0px; padding: 0px; border: 0px; outline: 0px; font-size: 0.7em; vertical-align: baseline; line-height: 1.5em; color: rgb(102, 102, 102); font-family: arial, sans-serif;"> Bart Jan Kullberg, M.D., Ph.D., and Maiken C. Arendrup, M.D., Ph.D.</p> <p class="citationLine" style="margin: 0px 0px 10px; padding: 0px; border: 0px; outline: 0px; font-size: 0.7em; vertical-align: baseline; line-height: 1.5em; color: rgb(102, 102, 102); font-family: arial, sans-serif;"> <span class="citation" style="margin: 0px; padding: 0px; border: 0px; outline: 0px; font-style: inherit; vertical-align: baseline;">N Engl J Med 2015; 373:1445-1456</span><a href="http://www.nejm.org/toc/nejm/373/15/" style="margin: 0px 0px 0px 3px; padding: 0px 0px 0px 3px; border-width: 0px 0px 0px 1px; border-left-style: solid; border-left-color: rgb(153, 153, 153); outline: 0px; font-style: inherit; vertical-align: baseline; color: rgb(0, 104, 146); text-decoration: none;">October 8, 2015</a><span class="doi" style="margin: 0px 0px 0px 3px; padding: 0px 0px 0px 3px; border-width: 0px 0px 0px 1px; border-left-style: solid; border-left-color: rgb(153, 153, 153); outline: 0px; font-style: inherit; vertical-align: baseline;">DOI: 10.1056/NEJMra1315399</span></p> </fieldset>