Title: Sepsis-3<br/>Author: Mike Winters<br/><a href='http://umem.org/profiles/faculty/141/'>[Click to email author]</a><hr/><p>
        <u><strong>Sepsis-3</strong></u></p>
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                After nearly 2 decades, the definitions for sepsis and septic shock have been updated.</li>
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                Key findings from the Task Force convened by SCCM and ESICM include:
                <ul>
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                                Sepsis
                                <ul>
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                                                Definition: life-threatening organ dysfunction due to a dysregulated host response to infection</li>
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                                                ICU patients: organ dysfunction is defined as an increase of 2 points or more in the Sequential Organ Failure Assessment (SOFA) score</li>
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                                                ED patients: 2 or more of the following new qSOFA (quickSOFA) score may identify patients with increased mortality
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                                                                SBP less than or equal to 100 mm Hg</li>
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                                                                RR less than or equal to 22</li>
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                                                                Altered mental status</li>
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                                Septic Shock
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                                                Definition: a subset of patients with sepsis and profound circulatory, cellular, and metabolic abnormalities</li>
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                                                Clinical Criteria:
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                                                                Persistent hypotension requiring vasopressors to maintain MAP greater than or equal to 65 mm Hg despite adequate volume resuscitation</li>
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                                                                Lactate greater than or equal to 2 mmol/L</li>
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                                The term "severe sepsis" is no longer used</li>
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<fieldset><legend>References</legend>

                <p>
        Singer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). <em>JAMA </em>2016; 315:801-10.</p>
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