Title: Buprenorphine/naloxone (Suboxone) exposure in pediatric population<br/>Author: Hong Kim<br/><a href='http://umem.org/profiles/faculty/526/'>[Click to email author]</a><hr/><p> Recently, a retrospective study of unintentional buprenorphine/naloxone exposure among pediatric population was published. All patients were evaluated by toxicologists at the time of initial hospital presentation (or transfer) at the study center.</p> <p> </p> <p> Bottom line</p> <ul> <li> 83% and 80% of the patients experienced respiratory and CNS depression, respectively.</li> </ul> <ul> <li> Majority of the patients became symptomatic within 8 hours of exposure (range not available).</li> </ul> <ul> <li> Naloxone reversed respiratory depression. Median dose for single naloxone dose: 0.09 mg/kg; median dose for multiple naloxone doses: 0.19 mg/kg.</li> </ul> <ul> <li> The reported “ceiling effect” on respiratory depression in adult does not exist in pediatric population.</li> </ul> <ul> <li> The optimal time of observation is unclear but it is prudent to observe pediatric buprenorphine exposure for up to 24 hours.</li> </ul>
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<fieldset><legend>References</legend>
<div class="cit" style="font-size: 0.8465em; line-height: 1.45em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"> <span role="menubar"><a abstractlink="yes" alsec="jour" alterm="Clin Toxicol (Phila)." aria-expanded="false" aria-haspopup="true" href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Clinical+effects+of+unintentional+pediatric+buprenorphine+exposure%3A+experience+at+a+single+tertiary+care+center.#" role="menuitem" style="color: rgb(102, 0, 102); border-bottom: 0px;" title="Clinical toxicology (Philadelphia, Pa.).">Clin Toxicol (Phila).</a></span> 2016 Oct 19:1-6. [Epub ahead of print]</div> <h1 style="font-size: 1.3em; margin: 0.375em 0px; line-height: 1.125em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"> <sub>Clinical effects of unintentional pediatric buprenorphine exposures: experience at a single tertiary care center.</sub></h1> <div class="auths" style="font-size: 0.923em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Toce%20MS%5BAuthor%5D&cauthor=true&cauthor_uid=27756148" style="color: rgb(102, 0, 102); border-bottom: 0px;">Toce MS</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Burns%20MM%5BAuthor%5D&cauthor=true&cauthor_uid=27756148" style="color: rgb(102, 0, 102); border-bottom: 0px;">Burns MM</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1,</span><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=O%27Donnell%20KA%5BAuthor%5D&cauthor=true&cauthor_uid=27756148" style="color: rgb(102, 0, 102); border-bottom: 0px;">O'Donnell KA</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1,</span><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">3</span>.</div> </fieldset>