Title: Vasopressor of choice in pediatric sepsis?<br/>Author: Mimi Lu<br/><a href='http://umem.org/profiles/faculty/185/'>[Click to email author]</a><hr/><p> Which first-line vasoactive drug is the best choice for children with fluid-refractory septic shock? A prospective, randomized, blinded study of 120 children compared dopamine versus epinephrine in attempts to answer this debated question in the current guidelines for pediatric sepsis.</p> <p> Bottom line: Dopamine was associated with an increased risk of death and healthcare–associated infection. Early administration of peripheral or intraosseous epinephrine was associated with increased survival in this population.</p>
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<fieldset><legend>References</legend>
<p class="details"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/27673385">Ramaswamy KN, Singhi S, Jayashree M, Bansal A, Nallasamy K. Double-Blind Randomized Clinical Trial Comparing <b>Dopamine</b> and <b>Epinephrine</b> in <b>Pediatric</b> Fluid-Refractory Hypotensive Septic Shock.</a><span class="jrnl" title="Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies">Pediatr Crit Care Med</span>. 2016 Nov;17(11):e502-e512.</p> </fieldset>