Title: Timing of Epi Administration in Cardiac Arrest Patients with Initial Shockable Rhythm<br/>Author: Kami Hu<br/><a href='http://umem.org/profiles/faculty/742/'>[Click to email author]</a><hr/><p>
In patients with persistent VT/VF cardiac arrest, giving epinephrine before the 2nd defibrillation attempt (which should follow initial shock and 2 minutes of CPR) is associated with decreased ROSC, decreased hospital survival, and decreased functional outcome. </p>
<p>
<u>Take Home Point</u>:</p>
<p>
"Electricity before Epi" in patients with persistent VT/VF arrest, at least for the initial epinephrine dose.</p>
<div align='center'>
<a href='http://www.umem.org/educational_pearls/3265/' target='_blank'><b>CLICK TO VIEW MORE IN-DEPTH INFORMATION</b></a><br/>
(Must disable pop-up blocker to open new window)
</div>
<fieldset><legend>References</legend>
<p>
<u>References:</u></p>
<p>
Part 7: Adult Advanced Cardiovascular Life Support: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Link MS, Berkow LC, Kudenchuk PJ, et al. <em>Circulation.</em> 2015;132(18 Suppl 2):S444-64.</p>
<p>
Early administration of epinephrine (adrenaline) in patients with cardiac arrest with initial shockable rhythm in hospital: propensity score matched analysis. Andersen LW, Kurth T, Chase M, et al. <em>BMJ.</em> 2016;353:i1577.</p>
</fieldset>