Title: Importance of hemodialysis in intubated salicylate poisoned patients<br/>Author: Hong Kim<br/><a href='http://umem.org/profiles/faculty/526/'>[Click to email author]</a><hr/><p>
Patients with severe salicylate poisoning may require endotracheal intubation due to fatigue from hyperventilation or mental status change.</p>
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A previously published study (Stolbach et al. 2008) showed that mechanical ventilation increases the risk of acidemia and clinical deterioration.</p>
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A small retrospective study investigated the impact of hemodialysis (HD) in intubated patients with salicylate poisoning.</p>
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</p>
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Findings:</p>
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53 cases with overall survival rate of 73.2%</p>
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In patients with salicylate level > 50 mg/dL</p>
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No HD: 56% survival (14/25)</li>
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HD: 83.9% survival (0/9)</li>
</ul>
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If salicylate level > 80 mg/dL</p>
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No HD: 0% survival (26/31)</li>
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HD: 83.3% survival (15/18)</li>
</ul>
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Bottom Line:</p>
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There is moratality benefit of HD in intubated salicylate-poisoned patient.</p>
<fieldset><legend>References</legend>
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McCabe DJ, Lu JJ. The association of hemodialysis and survival in intuated salicylate-poisoned patients. Amer J Emerg Med 2017;35:899-903.</p>
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Stolbach QI, Hoffman RS, Nelson LS. Mechanical ventilation was associated with acidemia in a case series of salicylate-poisoned patients. Acad Emerge Med 2008;15;866-869.</p>
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