Title: What is the best medication for acute extremity pain relief<br/>Author: Michael Bond<br/><a href='http://umem.org/profiles/faculty/78/'>[Click to email author]</a><hr/><p class="p1">
<span style="font-size:14px;"><span style="font-family:georgia,serif;">A recent article from JAMA (link below) showed that Ibuprofen and opioids are similarly effective in the short term relief of acute extremity pain when used in combination with acetaminophen.<span class="Apple-converted-space"> </span>The study looked at adults with fractures and sprains and randomized them to one of four groups.</span></span></p>
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<span style="font-size:14px;"><span style="font-family:georgia,serif;">400mg Ibuprofen and 1000mg acetaminophen</span></span></li>
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<span style="font-size:14px;"><span style="font-family:georgia,serif;">5mg Oxycodone and 325mg acetaminophen<span class="Apple-converted-space"> </span></span></span></li>
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<span style="font-size:14px;"><span style="font-family:georgia,serif;">5mg Hydrocodone and 300mg acetaminophen</span></span></li>
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<span style="font-size:14px;"><span style="font-family:georgia,serif;">30mg Codeine and 300mg acetaminophen</span></span></li>
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<span style="font-size:14px;"><span style="font-family:georgia,serif;">Pain relief was similar in all groups.</span></span></p>
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<span style="font-size:14px;"><span style="font-family:georgia,serif;">With the growing increase in opioid abuse/addiction it is good to know that in our patients that are not allergic to acetaminophen and ibuprofen (or all medications except for that one that begins with a “D”) we can provide good pain relief without using opioids.</span></span></p>
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<a href="http://https://jamanetwork.com/journals/jama/article-abstract/2661581"><span style="font-size:14px;"><span style="font-family:georgia,serif;">https://jamanetwork.com/journals/jama/article-abstract/2661581</span></span></a></p>
<fieldset><legend>References</legend>
<p class="p1">
Chang AK, Bijur PE, Esses D, Barnaby DP, Baer J. <b>Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Tria</b>l. JAMA. 2017 Nov 7;318(17):1661-1667. doi: 10.1001/jama.2017.16190.</p>
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