Title: Does Age of PRBCs Transfused Actually Matter?<br/>Author: Daniel Haase<br/><a href='http://umem.org/profiles/faculty/1447/'>[Click to email author]</a><hr/><p>
--Storage of red blood cell (RBC) products undergoe structural, biochemical and metabolic changes. Most blood banks issue the oldest compatible RBCs available.</p>
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--TRANSFUSE was a multicenter, randomized, double-blind trial to compare using the freshest vs. oldest compatible available blood products in <u>critically ill patients</u> in the ICU</p>
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--4664 patient enrolled, and there was no difference in mortality or clinically-significant adverse outcomes</p>
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--<u><strong>TAKE HOME</strong></u> --> No clinically meaningful benefit to transfusing freshest available blood products in critically ill patients</p>
<fieldset><legend>References</legend>
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Cooper DJ, McQuitten ZK, et al. Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults. NEJM. 2017; 377: 1858-1867. </p>
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