Title: Prophylactic Antibiotics for Post-Arrest Patients?<br/>Author: Mike Winters<br/><a href='http://umem.org/profiles/faculty/141/'>[Click to email author]</a><hr/><p>
<strong><u>Post-Arrest Prophylactic Antibiotics?</u></strong></p>
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Pneumonia is the most common infective complication in post-cardiac arrest patients. It may develop in up to 60% of patients and is associated with an increased ICU length of stay.</li>
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Given the challenges in diagnosing pneumonia in the post-cardiac arrest patient, many clinicians consider prophylactic antibiotic administration.</li>
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A recent systematic review and meta-analysis sought to evaluate the effect of early antibiotic use on survival and survival with good neurologic outcome in adult patients resuscitated from cardiac arrest. Key study results include:
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11 studies (3 RCTs, 8 observational trials)</li>
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6149 patients</li>
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No change in overall survival or survival with good neurologic outcome</li>
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<strong>Take Home Point: Current data does not support the prophylactic administration of antibiotics to adults resuscitated from cardiac arrest.</strong></li>
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<fieldset><legend>References</legend>
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Couper K, et al. Prophylactic antibiotic use following cardiac arrest: a systematic review and meta-analysis. <em>Resuscitation</em>. 2019; epub ahead of print.</p>
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