Title: Pulmonary complication from reversal of opioid overdose with naloxone<br/>Author: Hong Kim<br/><a href='http://umem.org/profiles/faculty/526/'>[Click to email author]</a><hr/><p> </p> <p> Pulmonary complications - aspiration, pulmonary edema, etc. are frequently reported in both heroin intoxication and in reversal of opioid overdose with naloxone. </p> <p> Suspected opioid overdose victims (N=1831) who received naloxone from EMS providers were studied retrospectively. Pulmonary complications were defined as pulmonary edema, aspiration pneumonia and aspiration pneumonitis.</p> <p> Results</p> <ul> <li> Out of hospital naloxone dose > 4.4 mg – 62% more likely of experiencing pulmonary complication (OR 2.14, 95% CI: 1.44 to 3.18) </li> <li> Increased risk of pulmonary complication if initial naloxone dose is > 0.4 mg (OR 2.57, 95% CI 1.45 to 4.54)</li> </ul> <p> </p> <p> <strong>Conclusion</strong></p> <p> Higher out of hospital naloxone administration is associated with increased odds of developing pulmonary complications</p> <fieldset><legend>References</legend>
<ol style="font-size: 16px; font-family: Calibri, Helvetica, sans-serif; margin-bottom: 0px; margin-top: 0px;"> <li style="margin-left: 15px;"> <font face="arial, sans-serif"><span class="m_4319119253879279586authors" font-size:="" sans="" source="" style="box-sizing: inherit; color: rgb(33, 33, 33); font-family: ">Farkas A, Lynch MJ, Westover R, Giles J, Siripong N, Nalatwad A, Pizon AF, Martin-Gill C. </span><a data-saferedirecturl="https://www.google.com/url?q=https://www.ncbi.nlm.nih.gov/pubmed/31182316/&source=gmail&ust=1563590888270000&usg=AFQjCNEz475XC-Xg2iK6h3J2BC5hXjzzMw" font-size:="" href="https://www.ncbi.nlm.nih.gov/pubmed/31182316/" sans="" source="" style="color: rgb(76, 44, 146); box-sizing: inherit; font-family: " target="_blank">Pulmonary Complications of Opioid Overdose Treated With Naloxone. </a><span class="m_4319119253879279586source" font-size:="" sans="" source="" style="box-sizing: inherit; color: rgb(33, 33, 33); font-family: ">Ann Emerg Med</span><span font-size:="" sans="" source="" style="color: rgb(33, 33, 33); font-family: ">. </span><span class="m_4319119253879279586pubdate" font-size:="" sans="" source="" style="box-sizing: inherit; color: rgb(33, 33, 33); font-family: ">2019 Jun 7;</span><span font-size:="" sans="" source="" style="box-sizing: inherit; color: rgb(33, 33, 33); font-family: ">. </span><span class="m_4319119253879279586doi" font-size:="" sans="" source="" style="box-sizing: inherit; color: rgb(33, 33, 33); font-family: ">doi: 10.1016/j.annemergmed.2019.04.<wbr />006. </span><span class="m_4319119253879279586pubstatus" font-size:="" sans="" source="" style="box-sizing: inherit; color: rgb(33, 33, 33); font-family: ">[Epub ahead of print] </span><span class="m_4319119253879279586pmid" font-size:="" sans="" source="" style="box-sizing: inherit; color: rgb(33, 33, 33); font-family: ">PubMed PMID: 31182316</span><span font-size:="" sans="" source="" style="box-sizing: inherit; color: rgb(33, 33, 33); font-family: ">.</span></font></li> </ol> </fieldset>