Title: drug-induced liver injury and its implicated agents<br/>Author: Hong Kim<br/><a href='http://umem.org/profiles/faculty/526/'>[Click to email author]</a><hr/><p>
         </p>
<p>
        Direct hepatotoxicity from a drug is predictable and dose-dependent.</p>
<p>
        Most commonly implicated agents include:</p>
<ul>
        <li style="margin-left:16.1pt;">
                Acetaminophen</li>
        <li style="margin-left:16.1pt;">
                Niacin</li>
        <li style="margin-left:16.1pt;">
                Aspirin</li>
        <li style="margin-left:16.1pt;">
                Cocaine</li>
        <li style="margin-left:16.1pt;">
                IV Amiodarone</li>
        <li style="margin-left:16.1pt;">
                IV methotrexate</li>
        <li style="margin-left:16.1pt;">
                Cancer chemotherapy</li>
</ul>
<p>
        On the contrary, idiosyncratic prescription drug-induce liver injury is rare, unpredictable and not related to dose.</p>
<p>
        Most commonly implicated agents are:</p>
<ol>
        <li>
                Amoxicillin-clavulanate</li>
        <li>
                Isoniazid</li>
        <li>
                Nitrofurantoin</li>
        <li>
                TMP-SMZ</li>
        <li>
                Miocycline</li>
        <li>
                Cefazolin</li>
        <li>
                Azithromycin</li>
</ol>
<p>
        <strong>Bottom line:</strong></p>
<ul>
        <li>
                Drug-induced liver injury is uncommon and can be a diagnostic challenge.</li>
        <li>
                Recognition of commonly implicated agents can help recognize/identify drug-induced liver injury. </li>
</ul>