Title: SARS-CoV-2 Infection in Children<br/>Author: Jenny Guyther<br/><a href='http://umem.org/profiles/faculty/314/'>[Click to email author]</a><hr/><div style="font-family: Arial, Helvetica, sans-serif; font-size: small;">
<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">New information is coming out each day. Below is just a sample of some of the recent data in children.</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">SARS-CoV2 Infection in Children - Lu et al</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">- 1391 Children in China were tested between 1/28-2/26/20. 171 were positive. </span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">- Fever was present in 41.5 % of infected children at some time during their illness course</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">- 3 patients required ICU care</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">- 27 patients did not have any symptoms or pneumonia on chest xray</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">Infant COVID Study - Wei et al</span></span>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">-2 month retrospective review</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">-9 <strong>i</strong>nfants under 1 year tested positive for COVID during this time period</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">-3/9 asymptomatic, 4/9 fever only, 2/9 mild URI symptoms</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">Children COVID Study - Xai et al</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">-2 week retrospective review</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">-20 children, all inpatients </span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">-12/20 fever (60%), 13/20 cough (65%)</span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">-Coinfection pathogens: influenza A, B, mycoplasma, CMV, RSV </span></span></div>
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<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;"><strong>Bottom line:</strong> Children appear to be less severely affected than adults and with a different symptom pattern. Coinfection with other respiratory viral pathogens can occur.</span></span></div>
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<fieldset><legend>References</legend>
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Lu et al. Correspondence: SARS-CoV-2 Infection in Children. NEJM. Accessed online 3/19/20 at <a data-saferedirecturl="https://www.google.com/url?q=https://www.nejm.org/doi/full/10.1056/NEJMc2005073&source=gmail&ust=1584792838172000&usg=AFQjCNGEdNV4JY2adQ_k6xYieEKx9Vll3Q" href="https://www.nejm.org/doi/full/10.1056/NEJMc2005073" style="color: rgb(17, 85, 204);" target="_blank">https://www.nejm.org/doi/full/<wbr />10.1056/NEJMc2005073</a>.</div>
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Wei et al. Research Letter: Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China. JAMA. Published online February 14, 2020. doi:10.1001/jama.2020.2131.</div>
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Xai et al. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatric Pulmonary. 2020; 1-6.</div>
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