Title: Erythrocyte sedimentation rate for evaluation of spinal infection<br/>Author: Brian Corwell<br/><a href='http://umem.org/profiles/faculty/294/'>[Click to email author]</a><hr/><p style="margin-left:.25in;">
<span style="font-size:16px;"><strong>Erythrocyte sedimentation rate (ESR) for spinal infection</strong></span></p>
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Sensitive for spinal infection but not specific</p>
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Elevated ESR is observed in greater than 80% of patients with vertebral osteomyelitis and epidural abscess</p>
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ESR is the most sensitive and specific serum marker for spinal infection</p>
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Usually elevated in acute presentations of SEA and vertebral osteomyelitis</p>
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<strong>ESR was elevated in 94-100% of patients with SEA vs. only 33% of non-SEA patients</strong></p>
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Mean ESR in patients with SEA was significantly elevated (51-77mm/hour)</p>
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Infection is unlikely in patients with an ESR less than 20 mm/h.</p>
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Incorporating ESR into an ED decision guideline may improve diagnostic delays and help distinguish patients in whom MRI may be performed on a non-emergent basis</p>
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<fieldset><legend>References</legend>
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1) Davis DP, et al. Prospective evaluation of a clinical decision guideline to diagnose spinal epidural abscess in patients who present to the emergency department with spine pain. J Neurosurg Spine 2011;14:765-767.</p>
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2) Reihsaus E, et al. Spinal epidural abscess: a meta-analysis of 915 patients. Neurosurg Rev 2000;23:175,204</p>
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