Title: Kcentra for Anticoagulant Reversal<br/>Author: Wesley Oliver<br/><a href='mailto:1911'>[Click to email author]</a><hr/><p> Kcentra (four-factor prothrombin complex concentrate, 4f-PCC) is approved for the reversal of warfarin using a weight-based dosing strategy based on INR. However, since the approval of Kcentra, data has shown a fixed-dose strategy and use for direct-acting oral anticoagulants (DOAC) is appropriate. There are even recommendations to use a fixed-dose for DOACs in some situations. Utilizing a fixed-dose strategy can help with decreasing drug preparation/delivery times and costs.</p> <p> </p> <p> Our institution now only uses a weight-based Kcentra dose of 50 units/kg for patients on DOACs with ICH or trauma-induced coagulopathy. All other patients receive a fixed-dose of Kcentra 1,500 units or 2,000 units based on anticoagulant and other criteria.</p> <p> </p> <p> Below is a diagram summarizing our current dosing strategy for Kcentra at our institution.</p> <p> </p> <p> <img alt="" src="data:image/png;base64,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" /></p> <p> ICH=intracerebral hemorrhage</p> <p> DOAC=direct-acting oral anticoagulant (rivaroxaban, apixaban, and edoxaban)</p> <p> </p> <p> <strong><u>Other points of interest at our institution:</u></strong></p> <ul> <li> Based on recommended monitoring parameters, patients may receive additional doses of Kcentra.</li> <li> Idarucizumab (Praxbind) is the preferred agent for dabigatran reversal.</li> </ul> <p> </p> <fieldset><legend>References</legend>
<p> Kcentra® [package insert]. CSL Behring, Marburg, Germany; 2013.</p> <p> https://labeling.cslbehring.com/PI/US/Kcentra/EN/Kcentra-Prescribing-Information.pdf</p> <p> </p> <p> Tomaselli GF, et al. 2020 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2020 Aug 4;76(5):594-622.</p> <p> </p> <p> University of Maryland Medical Center. 2021. Pre- and Peri-Procedural Management of Anticoagulation, Management of Bleeding in the Setting of Anticoagulation, Intracranial Hemorrhage, and Dilutional Coagulopathies. Internal guideline.</p> <p> </p> <p> </p> </fieldset>