Title: Effect of Low-Dose Droperidol on QTc Interval<br/>Author: Wesley Oliver<br/><a href='mailto:1911'>[Click to email author]</a><hr/><p dir="ltr"> A recent prospective cohort study investigated the effect of low-dose droperidol on QTc in an emergency department:</p> <ul dir="ltr"> <li> 68 patients</li> <li> Droperidol dose: median 1.875 mg (range: 0.625-2.5 mg)</li> <li> Given as a 2-minute bolus</li> <li> 94.1% received for headache management</li> <li> Mean change in QTc: +29.9 ms (SD 15)</li> <li> 17.6% (n=12) experienced QTc interval >=500 ms</li> <li> 4.4% (n=3) had a change >=+60 ms</li> <li> No serious arrhythmias or deaths</li> <li> 13.2% (n=9) had at least one non-serious event (restlessness and/or anxiety)</li> </ul> <p dir="ltr"> <br /> Low-dose droperidol has a small effect on QTc and most patients remained below 500 ms.</p> <fieldset><legend>References</legend>
<p> <span id="docs-internal-guid-24420adb-7fff-431c-bca8-ddf9632a7153"><span style="font-size: 12pt; font-family: Roboto, sans-serif; color: rgb(33, 33, 33); font-variant-numeric: normal; font-variant-east-asian: normal; vertical-align: baseline; white-space: pre-wrap;">Hernández-Rodríguez L, Bellolio F, Cabrera D, et al. Prospective real-time evaluation of the QTc interval variation after low-dose droperidol among emergency department patients. Am J Emerg Med. 2022 Feb;52:212-219.</span></span></p> </fieldset>