Title: The Poison is in the Dose When Oxygen is Not Your Friend <br/>Author: Rachel Wiltjer<br/><a href='http://umem.org/profiles/resident/2046/'>[Click to email author]</a><hr/><div class="OutlineElement Ltr SCXW134664638 BCX0" segoe="" style="margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; overflow: visible; cursor: text; clear: both; position: relative; direction: ltr; color: rgb(0, 0, 0); font-family: " ui="">
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Some things are easy, even reflexive, and one of those things is putting oxygen on cyanotic patients. Usually, this is a great thing. Blue = bad. Occasionally, though, blue = baseline and even in those patients who are too blue, you want to keep them closer to purple than pink. </p>
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This issue is commonly encountered in certain types of congenital heart disease and as well as through various phases of their repair. These include ductal dependent lesions, those with significant shunts, and single ventricle physiology. Oxygen functions as a pulmonary vasodilator and can increase or change the direction of shunting, directly impacting physiology by causing pulmonary overcirculation, increased strain on the right ventricle, and decreases in systemic circulation. </p>
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Helpful Hints:</p>
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1) Find out and shoot for the patient’s goal oxygen saturation range (many lesions will be 75%-85%). This may be available from parents, in the EMR, or by calling the child’s cardiac center if they are an established patient.</p>
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2) In an undiagnosed neonate with hypoxia and signs of heart failure (crackles, enlarged liver, edema to the sacrum and/or occiput) or if unresponsive to initial trial of oxygen, decrease FiO2 and titrate support (nasal cannula with blender to set FiO2, HFNC, NIPPV, or intubation if necessary) to address respiratory distress as well as evaluation and treatment for ductal dependent lesions. </p>
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3) You may still need to use additional FiO2 to obtain reasonable oxygen saturations, but titrate thoughtfully.</p>
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<fieldset><legend>References</legend>
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<span class="EOP SCXW245152610 BCX0" data-ccp-props="{" style="margin: 0px; padding: 0px; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; color: rgb(0, 0, 0); white-space: pre-wrap; font-size: 11pt; line-height: 19.425px; font-family: WordVisiPilcrow_MSFontService, Calibri, Calibri_EmbeddedFont, Calibri_MSFontService, sans-serif;">McMann, K. T, Schelonka R.L. Editorial: Oxygen for cyanotic neonates: Friend or foe? <em>Pediatric Health. </em>2010 Feb; 4(1): 1-3.</span></p>
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