Title: Transfusion Strategy in MI w/ Anemia<br/>Author: Sarah Dubbs<br/><a href='http://umem.org/profiles/faculty/655/'>[Click to email author]</a><hr/><p>
Hot off the NEJM press, published November 11, 2023:</p>
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<strong>Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia (Carson, Brooks, Hebert, et al Myocardial Ischemia and Transfusion (MINT) Investigators)</strong></p>
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Phase 3 interventional trial</li>
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Adult patients with STEMI or NSTEMI and Hgb <10 g/dL were randomly assigned to either of two strategies
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restrictive transfusion- threshold of 7-8 g/dL (transfusion was permitted but not required when the hemoglobin level was less than 8 and was strongly recommended when the level was less than 7 or when anginal symptoms were not controlled with medications)</li>
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liberal transfusion- threshold of 10 g/dL</li>
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Primary outcome measured was recurrent MI or death at 30 days</li>
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3504 pateints were included in this study. A primary-outcome event occurred in 295 of 1749 patients (16.9%) in the restrictive-strategy group and in 255 of 1755 patients (14.5%) in the liberal-strategy group. More specifically, death occurred in 9.9% of the patients with the restrictive strategy and in 8.3% of the patients with the liberal strategy; myocardial infarction occurred in 8.5% and 7.2% of the patients, respectively.</p>
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<strong>Conclusions from the study: Liberal transfusion strategy did NOT significantly reduce the risk of recurrent MI or death at 30 days. </strong></p>
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<fieldset><legend>References</legend>
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<span al.="" and="" bert="" brooks="" carson="" droid="" et="" fira="" font-size:="" helvetica="" i="" in="" infarction="" liberal="" myocardial="" or="" restrictive="" segoe="" strategy="" style="box-sizing: inherit; color: rgb(33, 33, 33); font-family: " transfusion="">N Engl J Med<span .="" 2023.="" droid="" fira="" font-size:="" helvetica="" november="" online="" published="" segoe="" span="" style="color: rgb(33, 33, 33); font-family: ">Carson JL, Brooks MM, Hébert PC, et al. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. </span><i droid="" engl="" fira="" font-size:="" helvetica="" j="" n="" segoe="" span="" style="color: rgb(33, 33, 33); font-family: ">. Published online November 11, 2023. doi:10.1056/NEJMoa2307983</i></span></p>
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