Title: Setting PEEP in the Intubated COPD Patient<br/>
Author: Mike Winters<br/>
<a href='mailto:mwinters@som.umaryland.edu'>[Click to email author]</a><hr/>
Link: <a href='https://umem.org/educational_pearls/4426/'>https://umem.org/educational_pearls/4426/</a><hr/><p><strong>PEEP in the Ventilated COPD Patient?</strong></p>
<ul>
<li>Patients with acute respiratory failure secondary to COPD often have dynamic hyperinflation and intrinsic PEEP (PEEPi).</li>
<li>Both dynamic hyperinflation and PEEPi adversely effect pulmonary mechanics, markedly increase the work of breathing, impair respiratory muscle function, and can result in hemodynamic compromise.</li>
<li>It has traditionally been felt that the application of external PEEP in the intubated COPD patient may worsen hyperinflation.</li>
<li>Importantly, external PEEP has been shown to improve ventilator synchrony and decrease the work of breathing.</li>
<li>PEEPi is measured using an end-expiratory hold maneuver in a passive, relaxed patient.</li>
<li>External PEEP can then be set to approximately 70% of PEEPi, followed by frequent monitoring of plateau pressures in a volume-cycled ventilation mode.</li>
</ul>
<fieldset><legend>References</legend><p>Jubran A. Setting positive end-expiratory pressure in the severely obstructive patient. <em>Curr Opin Crit Care</em>. 2024; 30:89-96.</p>
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