Title: Nontraumatic exertional rhabdomyolysis<br/>
Author: Brian Corwell<br/>
<a href='mailto:bcorwell@som.umaryland.edu'>[Click to email author]</a><hr/>
Link: <a href='https://umem.org/educational_pearls/4614/'>https://umem.org/educational_pearls/4614/</a><hr/><p>A northeast university was recently in the news when several members of the lacrosse team were hospitalized with rhabdomyolysis. 9 of 50 players who participated in the workout required hospitalization. This occurred after a single intense 45-minute workout led by an alum and recent graduate of the Navy Seal training program.</p>
<p>It was surprising to many that young, fit, athletes would be so affected from a single workout.</p>
<p>Nontraumatic exertional rhabdomyolysis occurs following intense physical activity especially in untrained individuals or those unaccustomed to the particular activity (for example a group of runners performing an intense HIIT workout).</p>
<p>Prolonged strenuous activity can result in rhabdomyolysis even in trained individuals in the absence of known risk factors or prior history.</p>
<p>Increased risk when natural cooling mechanisms are affected such as when the individual is taking medications with anticholinergic properties, or the individual is wearing heavy military gear or football equipment.</p>
<p>Increased risk with sickle cell trait.</p>
<p>Increased risk when that activity is performed in environments of severe heat and humidity.</p>
<p>Exercise routines that have a heavy eccentric focus increases risk of rhabdomyolysis.</p>
<p> An Eccentric exercise involves slow lengthening of muscles under load </p>
<p>Examples: the lowering phase of a barbell while performing a bench press or the downward phase of a pull up</p>
<p>Helpful kinetics:</p>
<p>Following the exertional event, the serum CK will rise within 2-12 hours, reaching its maximum in 1-3 days.</p>
<p>CK has a serum half-life of approximately 36 hours. </p>
<p>CK levels decrease at approximately 40% per day.</p>