Title: Empiric Cryopercipitate for your MHP?<br/>
Author: Robert Flint<br/>
<a href='mailto:rflint@som.umaryland.edu'>[Click to email author]</a><hr/>
Link: <a href='https://umem.org/educational_pearls/4639/'>https://umem.org/educational_pearls/4639/</a><hr/><p>There is uncertainty if adding cryopercipitate empirically to all mass hemorrhage protocols has any benefit to mortality, need for transfusion, or any other meaningful outcome. This small study suggests it does not and that we should save the addition of cryopercipitate to those with lab proven low fibrinogen levels. </p>
<p><img src="https://umem.org/files/uploads/content/pearls/8384A9DB-1B59-42CB-9A78-1FA22A4FEF42-671e3fb43ef57.jpg" alt="" /></p>
<fieldset><legend>References</legend><h2>Empiric Cryoprecipitate Transfusion in Patients with Severe Hemorrhage: Results from the US Experience in the International CRYOSTAT-2 Trial</h2>
<p>Van Gent, Jan-Michael DO, FACS; Kaminski, Carter W DO; Praestholm, Caroline BS; Pivalizza, Evan G MD; Clements, Thomas W MD; Kao, Lillian S MD, MS, FACS; Stanworth, Simon MD; Brohi, Karim MD; Cotton, Bryan A MD, MPH, FACS</p>
<p><em>Journal of the American College of Surgeons</em> <a href="https://journals.lww.com/journalacs/toc/2024/04000">238(4):p 636-643, April 2024.</a> | <em>DOI:</em> 10.1097/XCS.0000000000000938</p>
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