Title: Prehospital TXA administration<br/>
Author: Robert Flint<br/>
<a href='mailto:rflint@som.umaryland.edu'>[Click to email author]</a><hr/>
Link: <a href='https://umem.org/educational_pearls/4650/'>https://umem.org/educational_pearls/4650/</a><hr/><p>Administration of prehospital TXA was found to improve 28 day mortality and decrease the amount of blood required to be transfused without any increased risk of thromboembolism or seizure. Two grams of TXA was superior to one gram and no TXA. </p>
<p><img src="https://umem.org/files/uploads/content/pearls/7B01A6C7-9C8C-40E7-824A-8BFB5CB2C2C6-6730b6d78ff1d.jpg" alt="" /></p>
<fieldset><legend>References</legend><h2>Prehospital tranexamic acid is associated with a survival benefit without an increase in complications: Results of two harmonized randomized clinical trials</h2>
<p>Mazzei, Michael MD, MPH?; Donohue, Jack K. BA?; Schreiber, Martin MD; Rowell, Susan MD, MBA; Guyette, Francis X. MD; Cotton, Bryan MD; Eastridge, Brian J. MD; Nirula, Raminder MD; Vercruysse, Gary A. MD; O'Keeffe, Terence MD; Joseph, Bellal MD; Brown, Joshua B. MD, MSc; Neal, Matthew D. MD; Sperry, Jason L. MD, MPH</p>
<p><em>Journal of Trauma and Acute Care Surgery</em> <a href="https://journals.lww.com/jtrauma/pages/currenttoc.aspx">97(5):p 697-702, November 2024.</a> | <em>DOI:</em> 10.1097/TA.0000000000004315</p>
</fieldset>