<!doctype html>
<html>
<head>
<meta name="viewport" content="width=device-width" />
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8" />
<title></title>
<style>
/* -------------------------------------
GLOBAL RESETS
------------------------------------- */
img {
border: none;
-ms-interpolation-mode: bicubic;
max-width: 100%; }
body {
font-family: sans-serif;
-webkit-font-smoothing: antialiased;
font-size: 14px;
line-height: 1.4;
margin: 0;
padding: 0;
-ms-text-size-adjust: 100%;
-webkit-text-size-adjust: 100%; }
table {
border-collapse: separate;
mso-table-lspace: 0pt;
mso-table-rspace: 0pt;
width: 100%; }
table td {
font-family: sans-serif;
font-size: 14px;
vertical-align: top; }
/* -------------------------------------
TYPOGRAPHY
------------------------------------- */
h1,
h2,
h3,
h4 {
color: #000000;
font-family: sans-serif;
font-weight: 400;
line-height: 1.4;
margin: 0;
margin-top: 15px;
margin-bottom: 5px;
}
h1 {
font-size: 35px;
font-weight: 300;
text-align: center;
text-transform: capitalize; }
p,
ul,
ol {
font-family: sans-serif;
font-size: 14px;
font-weight: normal;
margin: 0;
Margin-bottom: 15px; }
p li,
ul li,
ol li {
list-style-position: inside;
margin-left: 5px; }
a {
color: #3498db;
text-decoration: underline; }
/* -------------------------------------
BUTTONS
------------------------------------- */
.btn {
box-sizing: border-box;
width: 100%; }
.btn > tbody > tr > td {
padding-bottom: 15px; }
.btn table {
width: auto; }
.btn table td {
background-color: #ffffff;
border-radius: 5px;
text-align: center; }
.btn a {
background-color: #ffffff;
border: solid 1px #3498db;
border-radius: 5px;
box-sizing: border-box;
color: #3498db;
cursor: pointer;
display: inline-block;
font-size: 14px;
font-weight: bold;
margin: 0;
padding: 12px 25px;
text-decoration: none;
text-transform: capitalize; }
.btn-primary table td {
background-color: #3498db; }
.btn-primary a {
background-color: #3498db;
border-color: #3498db;
color: #ffffff; }
/* -------------------------------------
OTHER STYLES THAT MIGHT BE USEFUL
------------------------------------- */
.last {
margin-bottom: 0; }
.first {
margin-top: 0; }
.align-center {
text-align: center; }
.align-right {
text-align: right; }
.align-left {
text-align: left; }
.clear {
clear: both; }
.mt0 {
margin-top: 0; }
.mb0 {
margin-bottom: 0; }
.preheader {
color: transparent;
display: none;
height: 0;
max-height: 0;
max-width: 0;
opacity: 0;
overflow: hidden;
mso-hide: all;
visibility: hidden;
width: 0; }
.powered-by a {
text-decoration: none; }
hr {
border: 0;
border-bottom: 1px solid #f6f6f6;
Margin: 20px 0; }
</style>
</head>
<body class="">
<div class="pearl row-fluid">
<div class="pearl-meta">
<h2><strong>Title:</strong> <a href="https://umem.org/educational_pearls/4652/">Pre-Hospital Intranasal Ketamine as Pain Adjunct for Trauma</a></h2>
<p><strong>Category:</strong> <a href="https://umem.org/educational_pearls/?category=6">Trauma</a></p>
<p><strong>Keywords:</strong> ketamine, trauma <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&term=ketamine+trauma+%22last+5+years%22[dp]&db=pubmed&pubmedfilters=true" target="_blank">(PubMed Search)<i class="icon-share" title="Opens in new window"></i></a> </p>
<p>
<strong>Posted:</strong> 11/14/2024 by <a href="https://umem.org/educational_pearls/?author=1912">Ashley Martinelli</a>
<br/>
<a href="https://umem.org/profiles/faculty/1912/">Click here to contact Ashley Martinelli</a>
</p>
</div>
<div class="pearl-body">
<p>An out-of-hospital, randomized, placebo-controlled, blinded, parallel group study was conducted in adult patients under the care of the city fire-based emergency medical services and the local level one trauma center. Adult male patients experiencing moderate to severe pain due to traumatic injuries received either 50mg of intranasal ketamine or placebo in addition to fentanyl after randomization in the field by the paramedic (a novel approach). The primary outcome was reduction of pain by 2 points 30 minutes after study drug administration.</p>
<p>199 patients were randomized with 107 receiving ketamine and 92 with placebo. Patients were young (30-40), and had a median weight of 83 kg. Pretreatment pain scores were 10/10 and patients presented to the ED 14 minutes after receiving study medication. The most common injuries were falls, MVC, and GSW. Half of the patients received IV fentanyl but others had IM or IN routes.</p>
<p>Ketamine receipt did not lead to a 2 point reduction in pain scores (36% vs 44.7% p = 0.22). There was no difference in pain at 3 hours, additional medications received, or total amount of analgesia received. Notably, there were no differences in adverse events.</p>
<h3>References</h3>
<p>McMullan JT, Droege CA, Chard KM, Otten EJ, Hart KW, Lindsell CJ, Strilka RJ. Out-of-Hospital Intranasal Ketamine as an Adjunct to Fentanyl for the Treatment of Acute Traumatic Pain: A Randomized Clinical Trial. Ann Emerg Med. 2024 Oct;84(4):363-373. doi: 10.1016/j.annemergmed.2024.04.018. Epub 2024 Jun 12. PMID: 38864781.</p>
<h3>View this pearl on the University of Maryland, Department of Emergency Medicine's website: <a href="https://umem.org/educational_pearls/4652/">https://umem.org/educational_pearls/4652/</a></h3>
</div>
</div>
</body>
</html>