Got Symptomatic Hypertension? Why not try Fenoldopam?
Fenoldopam is a rapid-acting vasodilator.
It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors.
Effective as nitroprusside, however, it has the advantages of increasing renal blood flow (6 times as potent as dopamine in producing renal vasodilitation) and sodium excretion
Not associated with the accumulation of toxic metabolites, and not requiring shielding from light.
Fenoldopam can be safely used in all hypertensive emergencies, and may be particularly beneficial in patients with renal insufficiency.
Dosing (Adult): After a starting dose of 0.1 to 0.3 mcg/kg/minute, the dose is titrated at 15 minute intervals, depending on the BP response. May be increased in increments of 0.05 to 0.1 mcg/kg/minute every 15 minutes until target blood pressure is reached. Maximal infusion rate reported in clinical studies: 1.6 mcg/kg/minute.
