UMEM Educational Pearls

Category: Pediatrics

Title: Oral morphine versus ibuprofen in postoperative orthopedic pain in children

Keywords: Pain control in children, opiates, NSAIDS, motrin, orthopedic (PubMed Search)

Posted: 1/19/2018 by Jenny Guyther, MD
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This was a randomized superiority trial of 0.5mg/kg of oral morphine every 6 hours to 10 mg/kg of ibuprofen every 6 hours in children 5-17 years old who had minor outpatient orthopedic surgeries.  There were 77 patients in each group.  Primary outcome was pain as rated on the Faces pain scale.  Secondary outcomes were additional analgesic requirements, adverse events, and unplanned visits to the doctor.

Bottom line: Oral morphine was not superior to ibuprofen and both drugs decreased pain with no difference in efficacy.  Morphine was associated with more adverse events.


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Category: Toxicology

Title: Liver dialysis for poisoning-MARS therapy

Keywords: Liver dialysis, MARS (PubMed Search)

Posted: 1/18/2018 by Kathy Prybys, DO (Emailed: 1/19/2018) (Updated: 1/19/2018)
Click here to contact Kathy Prybys, DO

Acute liver failure carries a high morbidity without liver transplantation. Liver support systems can act as “bridge” until an organ becomes available for the transplant procedure or until the liver recovers from injury. Artificial liver support systems temporally provide liver detoxification utilizing albumin as scavenger molecule to clear the toxins without providing synthetic functions of the liver (coagulation factors). One of the most widely used devices is the Molecular Adsorbent Recirculating System (MARS).This system has 3 different fluid compartments: blood circuit, albumin with charcoal and anion exchange column, and a dialysate circuit that removes protein bound and water soluble toxins with albumin.

  • Mars has been used in several case reports to treat acetaminophen, Amanita phalloides,Phenytoin, lamotrigine, theophylline, and calcilum channel blockers poisonings.
  • All the extracorporeal liver assist devices are able to remove biological substances (ammonia, urea, creatinine, bilirubin, bile acids, amino acids, cytokines, vasoactive agents) but the real impact on the patient's clinical course has still to be determined.

Bottom Line

MARS therapy could be a potentially promising life saving treatment for patients with acute poisoning from drugs that have high protein-binding capacity and are metabolized by the liver, especially when concomitment liver failure. Consider consultation and transfer of patients to liver center.




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Category: Orthopedics

Title: Concussion Where are we now?

Keywords: Head injury, concussion, sideline (PubMed Search)

Posted: 1/13/2018 by Brian Corwell, MD (Updated: 1/23/2018)
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Concussion – Where are we now?

The Sport Concussion Assessment Tool 5th edition (SCAT 5) was released in 2017

It is a standardized tool to assist health care professionals in the evaluation of sport associated concussions

It should be used for those 13 years and older (there is a child version for younger athletes)

Print and bring to the sideline for your next coverage event!

Some points to consider:

It should take at least 10 minutes to complete. Any less and you may not be performing the test correctly

The SCAT5 is the standard tool used in concussion assessment in the NCAA and NFL and other professional sports

Some symptoms of concussion appear over time. For example, an athlete may have zero or minimal symptoms immediately after yet be considerably symptomatic in 10 to 15 minutes.

               -Follow up screening evaluations are essential even in those with a negative initial sideline screening test

The SCAT5 should be used immediately after injury

               -Utility decreases post injury after days 3-5

               -The included symptom checklist has utility in tracking recovery

               -Attempt to perform in an environment free of distractions (crowd noise, bad weather)

The clinical utility of the SCAT5 can be enhanced by adding assessment of other factors such as reaction time, balance assessment, video-observable signs (if available) and oculomotor screening.

Tongue laceration is a common injury in children - occurring in the setting of falls and seizures. The most common location is the anterior dorsal portion of the tongue. Priorities are to evaluate for airway compromise (swelling, hematoma, bleeding) and retained foreign bodies (teeth fragments, etc). The vast majority of lacerations DO NOT require repair and do well with routine dental hygiene and antiseptic mouth wash. While there is no clear consensus for indications to repair, considerations include uncontrolled bleeding, airway compromise, wounds greater than 2 cm, and wounds that gape while the tongue is still in the mouth. Use large absorbable sutures (like 4-0 chromic gut). Check out this great video from EM:RAP -

Category: Toxicology

Title: Benefit of activated charcoal in large acetaminophen ( >= 40 gm) overdose.

Keywords: activated charcoal, large acetaminophen overdose, NAC dose (PubMed Search)

Posted: 1/11/2018 by Hong Kim, MD, MPH (Updated: 1/23/2018)
Click here to contact Hong Kim, MD, MPH

Acetaminophen (APAP) overdose is the leading cause of liver failure in the U.S. and Europe. Large APAP ingestion can result in hepatotoxicity despite the early initiation of n-acetylcysteine (NAC). 

A recently published study from Austrialia investigated the effect of activate charcoal and increasing the NAC dose for large APAP overdose patients (3rd bag: 100 to 200 mg/kg over 16 hours) during first 21 hours of NAC therapy

acetaminophen ratio (first APAP level taken between 4 to 16 hour post ingestion / APAP level on the Rumack nomogram line at that time point) was determined to compare APAP levels at different time points among study sample


first APAP level at 4 hour post ingestion = 400

APAP level on the Rumack APAP nomogram at 4 hour post ingestion = 150

APAP ratio = 400/150 = 2.67



  1. Activated charcoal (AC): if given within 4 hours, AC significantly decreased the APAP ratio (OR: 1.4 vs. 2.2)
  2. Increased dose of NAC during the first 21 hour significantly decreased the risk of hepatotoxicity (OR: 0.27; 95% CI: 0.08 - 0.94).



  1. Administration of AC in patients with history of large APAP overdose (>=40 gm) within 4 hour of ingestion can still be beneficial.
  2. Increasing NAC dosing (3rd bag in first 21 hour thearpy) may decrease the risk of hepatotoxicity. 

Note: Any increase in NAC dosing from the standard 21 hour therapy should be performed after consulting your regional poison center.

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Category: Neurology

Title: Reversible Cerebral Vasoconstriction Syndrome (RCVS)

Keywords: RCVS, thunderclap headache, migraine, SAH (PubMed Search)

Posted: 1/10/2018 by WanTsu Wendy Chang, MD
Click here to contact WanTsu Wendy Chang, MD

  • Reversible cerebral vasoconstriction syndrome (RCVS) is the second most common cause of thunderclap headache after aneurysmal subarachnoid hemorrhage (SAH) and the most common cause of recurrent thunderclap headaches.
  • Up to 40% of patients with RCVS have a history of migraine.
  • It is associated with selective serotonin reuptake inhibitors (SSRIs), triptans, cocaine, marijuana, tacrolimus, oral contraceptives, as well as the peripartum period.
  • Symptoms are often triggered by emotional stress, sexual activity, showering, straining, and physical exertion.
  • Although the vasoconstriction is reversible, it can cause intracranial hemorrhage, seizures, stroke, and coma.
  • Diagnosis is by history, cerebral angiography and exclusion of aneurysmal SAH.

Bottom Line: Consider RCVS in the differential of thunderclap headache and in patients who present with worse than usual migraine headache.

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Category: Critical Care

Title: Septic Cardiomyopathy

Posted: 1/9/2018 by Mike Winters, MD (Updated: 1/23/2018)
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Septic Cardiomyopathy

  • Cardiac dysfunction is common in patients with sepsis.
  • Though mulitiple definitions exist, sepsis cardiomyopathy (SCM) is generally defined as an "acute syndrome of cardiac dysfunction that is unrelated to ischemia in patients with sepsis".
  • Depending on the study, the incidence of SCM ranges anwywhere from 7% to 70%.
  • Risk factors for SCM include:
    • Male
    • Younger age
    • High lactate at admission
    • History of heart failure
  • The best approach to treating patients with SCM is to maximize your treatment of sepsis.
  • Dobutamine is no longer routinely recommended for SCM based solely on measurements of ScvO2.

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Patients with severe asthma exacerbations that are unresponsive to inhaled beta-agonists may require the use of epinephrine to control their symptoms.  When patients get to this point what route of administration should be used for the administration of epinephrine?

The most recent asthma guidelines (published in 2007) recommend the use of SubQ epinephrine 0.3-0.5 mg every 20 minutes for 3 doses.  Drug references typically list SubQ or IM epinephrine 0.01 mg/kg (~0.3-0.5 mg) every 20 minutes as appropriate routes of administration.  There is currently no data demonstrating that one route of administration is better than the other in patients with asthma; however, in other disease states, such as anaphylaxis, IM epinephrine is preferred due to the more rapid and reliable absorption over SubQ administration.

Auto-injectors that administer IM epinephrine 0.3 mg are available.  These auto-injectors may decrease the risk of medications error; however, they can be expensive.  SubQ administration requires the use of a syringe and a vial/ampule of 1 mg/mL epinephrine.

Bottom Line: Either SubQ or IM epinephrine administration is appropriate for patients with severe asthma exacerbations.  The preferred method at a given institution will be dictated by historical practice, risk of medication dosing errors, and drug cost.

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A recent study was undertaken to validate the 4A's Test for the assessment of delirium in the elderly, with particular focus on inpatient geriatric patients; it revealed that the tool had high sensitivity in detecting delirium, particularly in those with dementia or language barriers, in whom this diagnosis can often be difficult to make.  Further studies would be useful in a similar demographic of emergency department geriatric patients to confirm that this straightforward test is generalizable to the emergency department geriatric patient population.

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Category: Pediatrics

Title: In NAT, suspicion is key.

Keywords: NAT, non-accidental trauma, abusive head trauma, intra-abdominal injury, burns (PubMed Search)

Posted: 1/6/2018 by Megan Cobb, MD
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In addition to suspicion of NAT with traumatic brain injury and burns, remember these other high risk injuries and features:

- Duodenal injuries in children <4 y/o 

- Frena injuries in non-ambulating children

- Proximal and midshaft humeral fractures > supracondylar fractures 

- Any bruising on the trunk, ears, neck, or with larger size or pattern  

- Delay in seeking care, inconsistent history, mechanism inconsistent with developmental age, and blame of a sibling or other child inflicting harm are all historical features also high risk. 


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Category: Critical Care

Title: Peri-Intubation Cardiac Arrest

Keywords: endotracheal intubation, cardiac arrest, airway, respiratory failure (PubMed Search)

Posted: 1/2/2018 by Kami Hu, MD (Updated: 1/4/2018)
Click here to contact Kami Hu, MD

Although the data is limited, current published rates of in-hospital, non-operating room peri-intubation cardiac arrest (PICA) range from 2 to 6%.1,2,3

Several risk factors associated with PICA have been identified and include:

  • Preintubation hemodynamic instability (shock index ≥ 1 or systolic blood pressure < 90mmHg)1,2,3
  • Elevated Body Mass Index (and increased risk with every 10kg body weight)1
  • Use of succinylcholine as paralytic3
  • Intubation occurring within one hour of nursing shift change3

Other common findings:

  • Most PICA occurs within 10 minutes of rapid sequence induction (RSI)1,2
  • PEA is the initial recorded rhythm 80-100% of the time.1,2,3
  • Even if ROSC obtained, PICA is associated with higher rates of in-hospital mortality compared to patients requiring emergent intubation who do not experience cardiac arrest.1,2,3


Bottom Line:  Endotracheal intubation is one of the riskiest procedures we regularly perform as emergency physicians.

  • Resuscitate hypotensive patients prior to or concomitantly with RSI and/or have a vasopressor at the ready in patients with higher risk of cardiovascular collapse.
  • Consider use of vecuronium or rocuronium, rather than succinylcholine, in patients who require a paralytic for intubation but are at higher risk of hyperkalemia or have an unknown history. 

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Category: Pediatrics

Title: Pediatric Cervical Spine Injuries

Posted: 12/29/2017 by Rose Chasm, MD (Updated: 1/23/2018)
Click here to contact Rose Chasm, MD

Children less than 8 years, and especially infants, are more susceptible to upper cervical spine injury.  Moreover, validated decision rules for suspected cervical spine injury imaging have not been proven to be as sensitive or specific for children less than 8 years of age.

The pediatric cervical spine has greater elasticity of the ligamentous structures, while the cartilaginous structures are less calcified. An infant's neck musculature is underdeveloped, with a disproportionally large head.  These factors increase the risk of cervical spine injury, and can make it difficult to properly place protective cervical collars in infants while assessing them for injury. 

In very young children, consider placing padding under the shoulders to prevent abnormal flexion that can occur with placement of a cervical collar, and consider having a lower threshold to image if mechanism history or exam is concerning.

Children are not little adults!  Clinicians must acknowledge the anatomic differences, varying age-related ability to cooperate with examination, pediatric specific injury mechanisms, and decreased reliability of validated decision rules for imaging in children, especially when younger than 8 years old.

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Category: Neurology

Title: Cerebral Venous Thrombosis (CVT)

Keywords: headache, seizure, stroke, neurological deficit, thrombogenic (PubMed Search)

Posted: 12/27/2017 by Danya Khoujah, MBBS (Updated: 1/23/2018)
Click here to contact Danya Khoujah, MBBS

Cerebral venous thrombosis is a rare (but dangerous) cause of headaches and strokes in patients below the age of 50. It includes thrombosis of the cerebral veins and major dural sinuses. 
A d-dimer can NOT be used to rule it out, as it would be falsely negative in up to 40% of patients. A dry head CT is completely normal in 30% of patients, with nonspecific changes present in another 30%.

Take home: If you are considering the diagnosis, obtain a CT venography (95% sensitive) and don’t rely on a negative dimer or dry head CT.


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Category: Pediatrics

Title: What is the ideal observation time for a patient with croup who has received racemic epinephrine?

Keywords: Croup, epinephrine, discharge, observation (PubMed Search)

Posted: 12/15/2017 by Jenny Guyther, MD (Updated: 1/23/2018)
Click here to contact Jenny Guyther, MD

The peak age for croup is 6 months to 3 years.  The cornerstone of treatment is corticosteroids, traditionally dexamethasone.  With oral administration, the peak onset is 1-2 hours. Steroids shorten the duration of symptoms, reduce the need for nebulized epinephrine and decrease the need for intubation.

Racemic epinephrine has been used for moderate to severe croup and can show an improvement in patient symptoms for up to 120 minutes.  There is little evidence to suggest how long to observe the patient for recurrence of symptoms after racemic epinephrine was given.  Previous studies have suggested both 2 and 4 hour observation.

299 patients were included in this study.  136 patients were observed for 3.1 to 4 hours.  In the 3.1 to 4 hour group, 21 (7%) failed treatment, 19 of those patients required admission and 2 returned within 24 hours.  No patients who were discharged home after 4 hours returned to the emergency department within 24 hours.

Bottom Line: Consider a 4 hour period of observation after giving racemic epinephrine in order to decrease bounce backs.

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Category: Neurology

Title: A New DAWN for Stroke Intervention?

Keywords: DAWN, thrombectomy, mismatch, wake-up, stroke, penumbra (PubMed Search)

Posted: 12/13/2017 by WanTsu Wendy Chang, MD
Click here to contact WanTsu Wendy Chang, MD


  • The DAWN trial was a multicenter, randomized, open-label study comparing endovascular thrombectomy plus standard medical care with standard medical care alone for patients with:
    • Acute stroke symptoms
    • Last known well 6 to 24 hours earlier
    • Evidence of intracranial ICA or proximal MCA occlusion
    • Mismatch between clinical deficit and infarct volume on CTA or MRA
  • The study found that patients receiving thrombectomy plus standard medical care had improved functional independence at 90 days as defined by modified Rankin Scale (mRS) of 0, 1, or 2 (49% vs 13%).
  • The trial was stopped early based on prespecified interim analysis intended with the adaptive trial design.
  • While the two treatment groups were similar, with median NIHSS score of 17, they had small infarct volumes and short time from symptom observation (4.8 vs 5.6 hours) compared to time of patient's last known well (12.2 vs 13.3 hours). 
  • 88% of the patients had unwitnessed stroke onset (including wake-up strokes), thus it is possible that these patients had actual ischemia times closer to 6 hours, thereby reproducing similar results as prior thrombectomy trials.

Bottom Line: The use of neuroimaging to identify an ischemic penumbra that may benefit from thrombectomy may be considered even for patients with time of last known well beyond 6 hours.

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Sedating The Critically Ill Patient

  • Sedating critically ill ED patients can be challenging.
  • Excessive sedation is associated with a prolonged duration of mechanical ventilation, ICU LOS, and may increase mortality.
  • Important pearls to consider when managing these patients include:
    • Prioritize pain management first - may reduce the need for sedative medications
    • When possible, target a calm and interactive patient shortly after intubation - consider adding a atypical antipyschotic with propofol or dexmedetomodine
    • Use a validated tool (i.e., RASS) to dose opioids and sedative medications
    • Avoid continuous infusions of benzodiazepines

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Category: Orthopedics

Title: Iselin disease

Keywords: 5th metatarsal, fracture, overuse (PubMed Search)

Posted: 12/9/2017 by Brian Corwell, MD
Click here to contact Brian Corwell, MD

CC: 12yo boy presents with pain to base of 5th metatarsal


Osteochondrosis overuse syndromes associated with development of secondary ossification or apophyseal centers

Iselin disease – Osteochondrosis of 5th MT base

Lateral 5th foot pain with weight bearing and activity in early adolescence

Child may limp or walk on inner part of foot

               Adolescents:  Girls >10, Boys >12

               Commonly seen in soccer, basketball, gymnastics and dance

Exam: Tenderness to palpation at proximal 5th MT at peroneal brevis insertion

Area may show edema and redness

Pain with foot inversion and resisted eversion and dorsiflexion

XR: May be normal or show enlargement or fragmentation of epiphysis

Obliquely oriented small bony fleck at 5th MT base. Parallel to long axis of 5th MT. Best seen on oblique view. Unlike fractures which tend to be horizontally oriented.

Treatment: Immobilize for comfort if severe (walking boot) or simple activity modification if mild. Ice and calf muscle stretching.


Category: Toxicology

Title: Loperamide Cardiac Toxicity

Keywords: Loperamide, cardiotoxicity, QT prolongation (PubMed Search)

Posted: 12/7/2017 by Kathy Prybys, DO (Emailed: 12/8/2017) (Updated: 12/8/2017)
Click here to contact Kathy Prybys, DO


Loperamide (Imodium) is a common inexpensive over-the counter antidiarrheal agent. It acts peripherally at the mu opioid receptor to slow gastrointestinal motility and has no CNS effects at therapeutic doses due to it's low bioavailability and limited abillity to cross the blood brain barrier dependent on glycoprotein transport. In the past few years, reports of loperamide abuse causing serious cardio toxicity began to appear in the literature. Abused at daily doses of 25-200 mg to get high or and to treat symptoms of withdrawal. (therapeutic dose: 2-4 mg with a maximun of 8mg for OTC and 16mg for prescription). Loperamide has been called the "poor man's methadone".

At large doses, loperamide effects the cardiac sodium, potassium and calcium channels which prolongs the QRS complex  and can lead to ventricular arrhythmias, hypotension, and death. Clinical features includes:

  • QT prolongation
  • QRS widening
  • Ventricular arrythmias
  • Hypotension
  • Syncope
  • CNS depression


Take Home Point:

Consider loperamide as a possible cause of unexplained cardiac events including QT interval prolongation, QRS widening, Torsades de Pointes, ventricular arrhythmias, syncope, and cardiac arrest. Intravenouse sodium bicarbonate should be utilized to overcome blockade and may temporize cardiotoxic events. Supportive measures necessary may include defibrillation, magnesium, lidocaine, isoproternol, pacing, and extracorporeal life support.



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Category: Infectious Disease

Title: Risk Factors for Community Associated C. difficile Infection

Keywords: c. difficile, antibiotic (PubMed Search)

Posted: 12/2/2017 by Ashley Martinelli (Emailed: 12/6/2017) (Updated: 12/6/2017)
Click here to contact Ashley Martinelli

Community-associated Clostridium difficile infection (CA-CDI) represents 41% of all CDI cases annually.  The association of specific outpatient exposures was assessed in a case control study by Guh, et al. They reviewed the CDC’s active surveillance reporting from 10 states through the Emerging Infections Program (Maryland participates).

Cases: ≥18, + C. difficile stool specimen collected as an outpatient or within 3 days of hospitalization, with no overnight stay in a health care facility in the prior 12 weeks, and no prior CDI diagnosis

Controls: matched 1:1 for age and sex within the same surveillance catchment area as the case patient on the date of the collection specimen. Exclusion criteria: prior diagnosis of CDI, diarrheal illness, overnight stay in health care facility in the prior 12 weeks

Data Collection: telephone interview, standardized questionnaire or comorbidities, medication use, outpatient health care visits, household and dietary exposures in the prior 12 weeks

Results: 452 participants (226 pairs), over 50% were ≥ 60 years of age, 70.4% female, and 29% were hospitalized within 7 days of diagnosis, no patients developed toxic megacolon or required colectomy.

Cases had more health care exposures, including the emergency department (11.2% vs 1.4% p <0.0001), urgent care (9.9% vs 1.8%, p=0.0003). In addition, cases also reported higher antibiotic exposures (62.2% vs 10.3%, p<0.0001) with statistically significant higher exposure to cephalosporins, clindamycin, fluoroquinolones, metronidazole, and beta-lactam and/or beta-lactamase inhibitor combination. The most common antibiotic indications were ear or sinus infections, URI, SSTI, dental procedure, and UTI. No differences were found in household or dietary exposures.

Take-home point: This study highlighted the risk for CA-CDI infection for patients presenting to an ED and reiterates that exposures to fluoroquinolones, cephalosporins, beta-lactam and/or beta-lactamase inhibitor combinations, and clindamycin significantly increases the risk of CA-CDI infection. Reducing unnecessary outpatient antibiotic prescribing may prevent further CA-CDI. 36% of case patients did not have any antibiotic or outpatient health care exposure; therefore, additional risk factors may exist.

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Category: Critical Care

Title: ECMO in HIV/AIDS Patients

Posted: 12/5/2017 by Ashley Menne, MD (Updated: 1/23/2018)
Click here to contact Ashley Menne, MD

Severe acute respiratory failure among patients with PCP pneumonia, especially among those newly diagnosed with AIDS, remains a disease of high morbidity and mortality. Among those requiring mechanical ventilator support, the mortality rate has been reported between 50-70%.

According to ELSO guidelines, pharmacologic immunosuppression (specifically neurtrophil <400/mL) is a relative contraindication. Furthermore, a status predicting poor outcome despite ECMO should also be considered a relative contraindication.

That said, there are several case reports now of successful use of ECMO in AIDS patients, particularly those suffering with PCP pneumonia.

In a case report and literature review published in BMJ in Aug 2017, 11 cases of ECMO (including 1 VA) in AIDS patients were described.

  • 7 survived to hospital discharge (including 1 VA)
  • 2 survived to decannulation, but ultimately died in hospital
  • 2 died on ECMO
  • Length of ECMO runs in survivors varied between 4 days (VA) to 31 days


Bottom Line: HIV/AIDS is not an absolute contraindication to VV ECMO therapy in ARDS and may be particularly useful in the treatment of severe PCP pneumonia. Initiation of ECMO in this patient population should be considered on an individual case by case basis. 

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