UMEM Educational Pearls

Title: Heyde s Syndrome

Category: Cardiology

Keywords: Heyde s Syndrome, aortic stenosis, angiodysplasia (PubMed Search)

Posted: 9/30/2012 by Semhar Tewelde, MD (Updated: 11/22/2024)
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Aortic valve (AV) stenosis associated with gastrointestinal angiodysplasia

Proteolysis of Von Willebrand (type 2A) as it passes through the stenotic valve is one culprit of bleeding

Hemostatic abnormalities e.g. GI bleed are often corrected after AV replacement

Valve replacement is only recommended for cardiac symptoms

Vincentelli A, Susen S, et al. Acquired von Willebrand Syndrome in Aortic Stenosis. N Engl J Med 2003; 349:343-349