UMEM Educational Pearls

Category: Vascular

Title: Lytics for catheter occlusion

Keywords: catheter, lytics (PubMed Search)

Posted: 12/31/2007 by Rob Rogers, MD (Updated: 7/10/2020)
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Thrombolytic infusion for occluded central venous catheters

For patients with long-term indwelling central venous catheters (dialysis catheters, Hickmans, etc) who develop catheter occlusion, consider infusion of thrombolytic therapy for catheter salvage.

How do you do it, you ask?

  • Infuse 2 mg of tPA through the affected port
  • Can also use Urokinase if this is all you have

This treatment is very safe and is well tolerated.

Journal of Vascular Access, 2006