Critical interventions to optimize neurologic outcome in the post-cardiac arrest patient include optimizing hemodynamics, preventing lung injury, maintaining normal O2 and CO2 tensions, targeted temperature management, and treating the underlying cause of the arrest.
Current guidelines recommend the following:
Target MAP > 70 mm Hg with IVFs, vasopressors, and inotropes.
Use a low tidal volume strategy of 6 to 8 ml/kg predicted body weight.
Decrease FiO2 to maintain SpO2 94% to 97%.
Adjust RR to maintain PaCO2 35 to 45 mm Hg
Initiate TTM with the goal temperature between 32 to 36o C
References
Walker AC, Johnson NJ. Critical care of the post-cardiac arrest patient. Cardiol Clin. 2018; 36:419-428.
