Tranexamic Acid (TXA) is an antifibrinolytic agent that is a competitive inhibitor of plasminogen activation, and a non-competitive inhibitor of plasmin
Inhibits the breakdown of fibrin mesh allowing clot formation
Vial Concentration: 1000mg/10 mL
When is it Indicated?
Epistaxis/Oral Bleeds/Fistula Bleeds
Local application of injectable form of TXA
Dose: Gauze soaked with 500 mg (5 mL) applied topically to the site of bleeding
Trauma
Criteria for use: Significant hemorrhage or significant risk of hemorrhage in adult trauma patients (SBP <90 mmHg and/or HR >110 bpm)
Dose: 1g in 100 mL 0.9% NaCl infused over 10 minutes followed by 1g in 100 mL 0.9% NaCl over 8 hours
Adverse Reactions
Generally well tolerated
GI Disturbances: nausea, vomiting, diarrhea
Thrombotic Events
Hypersensitivity reactions: anaphylaxis and anaphylactoid reactions
Hypotension following rapid injection (maximum rate is 100 mg/minute)
