Keywords: mortality, predictors, MALA, pH, lactate (PubMed Search)
Metformin associated lactic acidosis (MALA) has a high rate of mortality, ranging from 25% to 50%. Lactate level and acidemia are frequently associated with poor clinical outcome in many disease/medical conditions (e.g. sepsis).
A study investigated, via meta-analysis, if lactate level and pH were predictive of mortality in MALA.
44 studies were identified from PubMed, EMBASE and Web of Science.
170 cases of MALA were included
pH and lactate were poor predictors of mortality based upon ROC curve