Category: Trauma
Keywords: transfusion, mass hemorrhage protocol, cryoprecipitate (PubMed Search)
Posted: 10/14/2023 by Robert Flint, MD
(Emailed: 10/29/2023)
(Updated: 8/14/2024)
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This large UK and US study looked at the addition of high dose cryoprecipitate to mass transfusion protocols and found: “Among patients with trauma and bleeding who required activation of a major hemorrhage protocol, the addition of early and empirical high-dose cryoprecipitate to standard care did not improve all cause 28-day mortality.”
Davenport R, Curry N, Fox EE, et al. Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial. JAMA. Published online October 12, 2023. doi:10.1001/jama.2023.21019