The authors conducted a pre- and post-implementation study after five North Carolina county EMS agencies switched to single dose epinephrine during out of hospital cardiac arrest treatment from the traditional multidose (every 3-5 minutes) protocol. They looked at 1 year before and 1 year after implementation. They found no difference in survival to discharge from the hospital in the two groups but there was less return to spontaneous circulation in the single dose group.
References
Ashburn, N. P., Beaver, B. P., Snavely, A. C., Nazir, N., Winslow, J. T., Nelson, R. D., … Stopyra, J. P. (2022). One and Done Epinephrine in Out-of-Hospital Cardiac Arrest? Outcomes in a Multiagency United States Study. Prehospital Emergency Care, 27(6), 751–757. https://doi.org/10.1080/10903127.2022.2120135
