Department of Emergency Medicine

UMEM Educational Pearls

Title: Coagulopathic Contraindications for tPA use in Stroke

Category: Neurology

Keywords: coagulopathic, tPA, stroke, coagulopathy (PubMed Search)

Posted: 9/18/2008 by Aisha Liferidge, MD (Updated: 11/21/2024)
Click here to contact Aisha Liferidge, MD

tPA should NOT be used to treat ischemic stroke in the following instances:

  • Platelet count < 100,000
  • INR > 1.7 or PT > 15
  • Heparin administration within past 48 hours with subsequent PTT above upper limits of normal

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