UMEM Educational Pearls

Category: Toxicology

Title: Clevidipine - A new IV calcium channel blocker

Keywords: Clevidipine, calcium channel antagonist, calcium channel blocker, antihypertensive (PubMed Search)

Posted: 3/5/2009 by Ellen Lemkin, MD, PharmD (Updated: 9/24/2021)
Click here to contact Ellen Lemkin, MD, PharmD

Clevidipine

  • A new intravenous antihypertensive agent
  • Has a very rapid onset (2-4 min) and offset (5-15 min), in contrast to the available IV calcium channel blocker nicardipine, which has a duration of action of 3-6 hours
  • Contraindicated in patients with soy or egg allergies, and in those with defective lipid metabolism
  • Most common ADR's reported were headache, nausea, and vomiting
  • Initiate at 1-2 mg/hr, most respond at doses between 4-6 mg/hr
  • Maximum recommended dose is 16 mg/hr
  • Costs between $86 to $140 per 50 mg vial

References

1. Anon. The Medical Letter. Sept 22 2008;50(1295)73-4.