University of Maryland School of Medicine

Department of Emergency Medicine

University of Maryland School of Medicine Department of Emergency Medicine

UMEM Educational Pearls

 

  • Many infants w/cyanotic heart disease only survive w/early surgical intervention
  • The most rapid & effective first-line therapy for stabilization of the crashing neonate is IV prostaglandin E1 (PGE1)
  • PGE1 serves to reopen the ductus arteriosus allowing partially desaturated systemic arterial blood to enter the pulmonary artery and be oxygenated
  • The widespread use of this agent has profoundly decreased morbidity & mortality 
  • The initial dose of PGE1 is 0.1 mg/kg/min
  • ADR for PGE1 include: apnea, hypotension, edema, and low grade fever

References

 

Flanagan MF, Taylor DC. "Cardiac Disease". In Avery GB, Fletcher MA, MacDonald MC, eds. Neonatology. Philadelphia: J.B. Lippincott. 1994:519.
Turley K. Intermediate results from the period of the Congenital Heart Surgeons Society Transposition Study 1985-1989. Ann Thorac Surg. 1995;60:505-510.