UMEM Educational Pearls

Category: Toxicology

Title: Intravenous Phenergan

Keywords: Promethazine (PubMed Search)

Posted: 10/24/2013 by Fermin Barrueto, MD (Updated: 12/14/2019)
Click here to contact Fermin Barrueto, MD

If you are still using IV Phenergan, you need to be aware of the necrotic effect that occurs if it infiltrates. EDs have even removed it from their drug dispensing machines. It appears to be the drug and not the diluent. Mechanism is not completely understood. Below is a picture the plaintiff attorney will use about this well know adverse effect. If so many alternatives for IV antiemetic it is wise to reconsider IV phenergan.


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