UMEM Educational Pearls

Category: Toxicology

Title: Radiocontrast-Induced Nephropathy

Keywords: radiocontrast, nephropathy, renal failure (PubMed Search)

Posted: 11/29/2007 by Fermin Barrueto, MD (Updated: 7/10/2020)
Click here to contact Fermin Barrueto, MD

  • Risk Factors for RCIN: Renal insufficiency, >60 yr old, DM, Renal Transplant, Hypovolemia, EF <30%, concomitant nephrotoxic drugs
  • Consider Prophylaxis with anyone of three methods (no method has been found superior.
    • Normal Saline: 1 ml/kg/h IV pre and post study
    • NaHCO3: 3 ml/kg IV bolus over 1 hr then 1 ml/kg/h pre and post
    • IV Acetylcysteine 150 mg/kg bolus over 1hr then 50 mg/kg over 4h