UMEM Educational Pearls

Category: Toxicology

Title: Anti-Emetics

Keywords: ondansetron,metoclopramide (PubMed Search)

Posted: 12/7/2007 by Fermin Barrueto, MD (Updated: 7/10/2020)
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Everything you need to know about anti-emetics, mechanism of action, potency and toxicity:

1) 5-HT3 Blockers - Ondansetron, Granistron

- The most potent anti-emetic, only toxicity is really cost

2) Dopamine Blockers - Metoclopramide

- Can titrate to high doses, causes dystonia, akathisia and mild QT prolongation

3) Anticholinergic - Promethazine, meclizine, diphenhydramine

- Cannot titrate, most sedating, urinary retention in elderly, mild QT prolongation