UMEM Educational Pearls

Category: Toxicology

Title: Drugs that Alter the Thyroid

Keywords: thyroid, hypothyroid, hyperthyroid (PubMed Search)

Posted: 12/14/2007 by Fermin Barrueto, MD (Updated: 7/10/2020)
Click here to contact Fermin Barrueto, MD

Lithium: Hypothyroidism (5-15% of pts) and goiter (37% of pts), mechanism unclear

Amiodarone (37% Iodine by weight): Hyper or Hypothroidism

Beta-Blockers: by blocking peripheral conversion of T4 to T3 cause hypothyroidism

Corticosteroid: same as beta-blockers but can also cause transient thyrotoxicosis (Jod-Basedow effect)

Iodine, Iodinated contrast, radiactive iodine all can cause hypothyroidism but iodinated contrast material can actually induce thyrotoxicosis and thyroid storm from unknown mechanism.