UMEM Educational Pearls

Category: Toxicology

Title: Levetiracetam (Keppra)

Keywords: anticonvulsant, status epilepticus, keppra (PubMed Search)

Posted: 1/3/2008 by Fermin Barrueto, MD (Updated: 7/10/2020)
Click here to contact Fermin Barrueto, MD

Levetiracetam

  • A new anticonvulsant that is 100% renally eliminated
  • Does not require therapeutic drug monitoring like phenytoin
  • The IV form does not cause skin necrosis or have cardiotoxicity like phenytoin
  • Is being investigated in benzodiazepine-refracory status epilepticus (1)
  • Fairly safe drug even in overdose (Barrueto et al ;) )

 

Knake et al. Intravenous levetriacetam in thetreatment of benzodiazepine-refractory status epilepticus. J Neurol Neurosurg Psychiatry 2007 Sept 26; Epub