Category: Critical Care
Keywords: vasopressor, norepinephrine, timing, septic shock (PubMed Search)
Posted: 12/5/2023 by Quincy Tran, MD, PhD
(Updated: 8/14/2024)
Click here to contact Quincy Tran, MD, PhD
Settings: systemic review and meta-analysis
Participants: 2 RCTs, 21 observational studies. Fifteen studies were published between 2020-2023.
There was a total of 25721 patients with septic shock
Outcome measurement: Primary outcome was short-term mortality (ICU, hospital, 28-day, 30-day). Secondary outcomes included ICU LOS, Hospital LOS, time to achieve MAP > 65 mm Hg,
Study Results:
Composite outcome of short term mortality:
Secondary outcome:
Discussion:
Conclusion:
More and more studies, although a RCT is still necessary, are showing that early initiation of vasopressor within 1-6 hours of septic shock would be more beneficial to patients with septic shock.
Ye E, Ye H, Wang S, Fang X. INITIATION TIMING OF VASOPRESSOR IN PATIENTS WITH SEPTIC SHOCK: A SYSTEMATIC REVIEW AND META-ANALYSIS. Shock. 2023 Nov 1;60(5):627-636. doi: 10.1097/SHK.0000000000002214. Epub 2023 Sep 2. PMID: 37695641.