UMEM Educational Pearls

Category: Toxicology

Title: Salicylate Serum Concentrations - Be Wary

Keywords: Salicylate, aspirin, metabolic acidosisM (PubMed Search)

Posted: 7/17/2008 by Fermin Barrueto, MD (Updated: 12/7/2019)
Click here to contact Fermin Barrueto, MD

  •  Therapeutic concentration considered 10-20 mg/dL
  •  Some hospitals report in "mg/L" thus a level of 110 mg/L is therapeutic
  •  Symptoms of Toxicity usually > 40 mg/dL
  •  Consider Hemodialysis in any patient with a serum concentration >100 mg/dL

First Line Therapy:  Urine Alkalinization (pH >7.5) by administrating NaHCO3

Other Indications for Hemodialysis in Salicylate Poisoned Patient:

  1. Renal Failure
  2. CHF
  3. Acute Lung Injury
  4. Persistent CNS disturbances
  5. Refractory metabolic acidosis or electrolyte abnormality
  6. Hepatic insufficiency with coagulopathy