UMEM Educational Pearls

Category: Toxicology

Title: Bisphenol-A: A national concern

Keywords: bisphenol A, diabetes (PubMed Search)

Posted: 10/16/2008 by Fermin Barrueto, MD (Updated: 2/18/2020)
Click here to contact Fermin Barrueto, MD

Bisphenol A (BPA) is found in epoxy resins that line common food and beverage materials. There has been concern that this compound, like phthalates, may be causing harm through chronic low exposure. An epidemiologic study was performed and published in JAMA that has raised this question. Amazingly, the study did find that:

  • Higher urinary BPA levels correlated with an increase incidence of: NIDDM, CAD and elevated liver enzymes
  • Mechanism may be an estrogen effect, disruption of Beta-islet cell function and even obesity promoting effects
  • Study was strictly epidemiologic but raises a serious public health concern that you will see in the news more

References

Lange et al. JAMA 2008; 300(11): 1303-1310.