UMEM Educational Pearls

Category: Toxicology

Title: Aripiprazole - All you need to know

Keywords: atypical antipsychotic, aripiprazole (PubMed Search)

Posted: 9/24/2009 by Fermin Barrueto, MD (Updated: 8/20/2019)
Click here to contact Fermin Barrueto, MD

Aripiprazole (Abilify): a new atypical antipsychotic partially agonizes D2 and serotonin receptors though its compelte mechanism is not known. Used in schizophrenia, in overdose you may see the following symptoms (from a retrospective study done over 4 years worth of calls to a PCC):

  • Somnolence 89 (56%)
  • Tachycardia 32 (20%, heart rate 102-186)
  • Nausea/vomiting 29 (18%)
  • Dystonic reactions 21 (13%)

The study was with over 255 patients. Though QT prolongation is listed, it is not common with this medication.

 

References

Young MC, et al. Risk assessment of isolated aripiprazole exposures and toxicities: a retrospective study. Clin Tox 2009; 47(6): 580-3.