UMEM Educational Pearls

Category: Neurology

Title: First Time Seizures in Pregnancy

Keywords: pregnancy, seizure, epilepsy, first time seizure (PubMed Search)

Posted: 10/14/2009 by Aisha Liferidge, MD (Updated: 12/3/2022)
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  • Pregnant patients presenting with their first seizure, should essentially be managed in the same way as any other adult patient (i.e. Is the source of the seizure due to a reversible systemic condition, and if not, is the patient at risk for recurrent unprovoked seizures; specialist follow-up arrangement).
  • Additional pregnancy-related conditions that can be associated with seizure, such as eclampsia and cerebral venous thrombosis, should be considered.
  • While the safety of all anti-epileptic drugs in pregnancy is questionable, the use of valproate (Depakote) should definitely be avoided, given its compelling association with fetal malformations.